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腾讯登录EHP：指甲油、发胶或增加糖尿病风险
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据国外媒体报道，《环境卫生展望》（<em>Environment Health Perspectives</em>）上发表了一项最新研究表明，指甲油、发胶以及香水等美护产品中常见的一种化学成分可能会增加女性患糖尿病的风险。这种化学成分叫做邻苯二甲酸酯，个人护理产品、粘合剂、电子产品，以及汽车、玩具和各类包装材料中均含有该成分。邻苯二甲酸酯能够改变身体某些机能的正常运行规律，导致内分泌失调，从而增加患糖尿病和肥胖症的风险。研究人员对2350名女性的尿样分析后发现，体内邻苯二甲酸单苄酯和邻苯二甲酸单异丁基酯浓度最高的女性患糖尿病的风险是浓度最低女性的两倍。不过，研究人员也指出，因为该化学成分广泛存在于各类产品中，想要避免接触到该成分也是件困难的事情；日常生活中，人们可以通过勤除尘、勤洗手来避免该成分进入体内。
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<a title="" href="http://dx.doi.org/10.1289/ehp.1104717" target="_blank">doi:10.1289/ehp.1104717</a>
PMC:
PMID:
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<br/><strong>Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008 </strong><br/>
Tamarra James-Todd, Richard Stahlhut, John D. Meeker, Sheena-Gail Powell, Russ Hauser, Tianyi Huang, Janet Rich-Edwards
Background: Previous studies show women to have higher urinary concentrations of several phthalate metabolites compared to men, possibly due to higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors in women.
Objective: Explore the association between urinary phthalate metabolite concentrations and diabetes among women in a cross-sectional study.
Methods: We utilized data from CDC-analyzed urinary concentrations of phthalate metabolites and self-reported diabetes in 2,350 women ages 20-<80 participating in the NHANES (2001-2008). We used multiple logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for urinary creatinine, sociodemographic and dietary factors, and body size. A secondary analysis was conducted in women without diabetes to evaluate the association between phthalate metabolite concentrations and fasting blood glucose, HOMA-IR, and hemoglobin A1c.
Results: After adjusting for potential confounders, women with higher levels of MnBP, MiBP, MBzP, MCPP, and ∑DEHP had an increased odds of diabetes compared to women with the lowest levels of these phthalates. Women in the highest quartile for MBzP and MiBP had almost twice the odds of diabetes (OR 1.96, 95% CI: 1.11, 3.47 and OR 1.95, 95% CI: 0.99, 3.85, respectively) compared to women in the lowest quartile. Non-monotonic, positive associations existed for MnBP and ∑DEHP, while MCPP appeared to have a threshold effect. Certain phthalate metabolites were positively associated with fasting glucose and insulin resistance.
Discussion: Urinary levels of several phthalates were associated with prevalent diabetes. Future prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism, and increase the risk of insulin resistance and diabetes.
<br/>来源：中国日报网
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据国外媒体报道，《环境卫生展望》（<em>Environment Health Perspectives</em>）上发表了一项最新研究表明，指甲油、发胶以及香水等美护产品中常见的一种化学成分可能会增加女性患糖尿病的风险。这种化学成分叫做邻苯二甲酸酯，个人护理产品、粘合剂、电子产品，以及汽车、玩具和各类包装材料中均含有该成分。邻苯二甲酸酯能够改变身体某些机能的正常运行规律，导致内分泌失调，从而增加患糖尿病和肥胖症的风险。研究人员对2350名女性的尿样分析后发现，体内邻苯二甲酸单苄酯和邻苯二甲酸单异丁基酯浓度最高的女性患糖尿病的风险是浓度最低女性的两倍。不过，研究人员也指出，因为该化学成分广泛存在于各类产品中，想要避免接触到该成分也是件困难的事情；日常生活中，人们可以通过勤除尘、勤洗手来避免该成分进入体内。
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<div id="ztload">
<div>
<div>
<img src="http://www.bioon.com/biology/UploadFiles/201205/2012050411270561.jpg" alt="" width="113" height="149" border="0" />
<a title="" href="http://dx.doi.org/10.1289/ehp.1104717" target="_blank">doi:10.1289/ehp.1104717</a>
PMC:
PMID:
</div>
<div>
<br/><strong>Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008 </strong><br/>
Tamarra James-Todd, Richard Stahlhut, John D. Meeker, Sheena-Gail Powell, Russ Hauser, Tianyi Huang, Janet Rich-Edwards
Background: Previous studies show women to have higher urinary concentrations of several phthalate metabolites compared to men, possibly due to higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors in women.
Objective: Explore the association between urinary phthalate metabolite concentrations and diabetes among women in a cross-sectional study.
Methods: We utilized data from CDC-analyzed urinary concentrations of phthalate metabolites and self-reported diabetes in 2,350 women ages 20-<80 participating in the NHANES (2001-2008). We used multiple logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for urinary creatinine, sociodemographic and dietary factors, and body size. A secondary analysis was conducted in women without diabetes to evaluate the association between phthalate metabolite concentrations and fasting blood glucose, HOMA-IR, and hemoglobin A1c.
Results: After adjusting for potential confounders, women with higher levels of MnBP, MiBP, MBzP, MCPP, and ∑DEHP had an increased odds of diabetes compared to women with the lowest levels of these phthalates. Women in the highest quartile for MBzP and MiBP had almost twice the odds of diabetes (OR 1.96, 95% CI: 1.11, 3.47 and OR 1.95, 95% CI: 0.99, 3.85, respectively) compared to women in the lowest quartile. Non-monotonic, positive associations existed for MnBP and ∑DEHP, while MCPP appeared to have a threshold effect. Certain phthalate metabolites were positively associated with fasting glucose and insulin resistance.
Discussion: Urinary levels of several phthalates were associated with prevalent diabetes. Future prospective studies are needed to further explore these associations to determine whether phthalate exposure can alter glucose metabolism, and increase the risk of insulin resistance and diabetes.
<br/>来源：中国日报网
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