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腾讯登录AJCN：维生素D3对人类机体健康或更有益处
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近日，来自英国生物技术及生物科学研究理事会（BBSRC）的一项研究指出，机体补充维生素D3相比其近亲维生素D2有更多的益处。相关研究成果刊登在了近日的国际杂志<em>The American Journal of Clinical Nutrition</em>上，这项研究或许为食品工业的强化可以提供一些意见。
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维生素D（Vitamin D）对于骨骼和肌肉的发育至关重要，而且有研究表明，人类比没有通过足够的日照而或许定量的维生素D。因此日常生活的饮食中需要添加维生素D，一般情况下添加的是维生素D2，这种维生素动物机体并不能产生。然而，近日的这项研究指出，维生素D3相比另外两种类型的维生素D对机体更有益处。
<p align="center"><img src="http://www.bioon.com/biology/UploadFiles/201206/2012060312122665.jpg" alt="" width="255" height="219" border="0" /></p>
<p align="center"><span style="font-family: 楷体_GB2312; font-size: x-small;">The Structure of Vitamin D3</span></p>
研究者表示，维生素D3存在于鸡蛋和富含油的鱼类中，而且在机体内可以高效转化为机体健康所需的激素。领导此项研究的Laura Tripkovic博士解释道：“我们都知道维生素D可以帮助我们保持健康的状态，但是我们并不清楚不同类型的维生素D之间的差异性。通常大家都认为几种维生素D的功效是一样的，然而我们的研究指出，机体对于不同类型的维生素D的反应不尽一样，而且维生素D3对于机体是最有好处的。、
研究者分析了10个独立实验、共涉及1000人的实验数据，对比了维生素D2和D3的效应，发现维生素D3的摄入可以明显增加机体血清中的维生素D水平。
如今，研究者设计了一项新的实验，研究者在食物中添加低剂量的维生素D2和D3，试图研究是否可以得到上述类似的结果，如果维生素D3的好处确实比其它类型维生素D多，那么人们补充维生素D3将会大大保持自身的健康程度。
<br/><strong>编译自</strong><br/>
：<a href="http://www.sciencedaily.com/releases/2012/05/120531102338.htm">http://www.sciencedaily.com/releases/2012/05/120531102338.htm</a>
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<a title="" href="http://dx.doi.org/doi:10.3945/ajcn.111.031070" target="_blank">doi:10.3945/ajcn.111.031070</a>
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PMID:
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<br/><strong>Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis1,2,3</strong><br/>
Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppönen, Jacqueline Berry, Reinhold Vieth, and Susan Lanham-New
Background: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]. Objective: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans. Design: The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials. Results: A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation. Conclusions: This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3 could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.
<div><br/>来源：生物谷 </div>
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近日，来自英国生物技术及生物科学研究理事会（BBSRC）的一项研究指出，机体补充维生素D3相比其近亲维生素D2有更多的益处。相关研究成果刊登在了近日的国际杂志<em>The American Journal of Clinical Nutrition</em>上，这项研究或许为食品工业的强化可以提供一些意见。
<!--more-->
维生素D（Vitamin D）对于骨骼和肌肉的发育至关重要，而且有研究表明，人类比没有通过足够的日照而或许定量的维生素D。因此日常生活的饮食中需要添加维生素D，一般情况下添加的是维生素D2，这种维生素动物机体并不能产生。然而，近日的这项研究指出，维生素D3相比另外两种类型的维生素D对机体更有益处。
<p align="center"><img src="http://www.bioon.com/biology/UploadFiles/201206/2012060312122665.jpg" alt="" width="255" height="219" border="0" /></p>
<p align="center"><span style="font-family: 楷体_GB2312; font-size: x-small;">The Structure of Vitamin D3</span></p>
研究者表示，维生素D3存在于鸡蛋和富含油的鱼类中，而且在机体内可以高效转化为机体健康所需的激素。领导此项研究的Laura Tripkovic博士解释道：“我们都知道维生素D可以帮助我们保持健康的状态，但是我们并不清楚不同类型的维生素D之间的差异性。通常大家都认为几种维生素D的功效是一样的，然而我们的研究指出，机体对于不同类型的维生素D的反应不尽一样，而且维生素D3对于机体是最有好处的。、
研究者分析了10个独立实验、共涉及1000人的实验数据，对比了维生素D2和D3的效应，发现维生素D3的摄入可以明显增加机体血清中的维生素D水平。
如今，研究者设计了一项新的实验，研究者在食物中添加低剂量的维生素D2和D3，试图研究是否可以得到上述类似的结果，如果维生素D3的好处确实比其它类型维生素D多，那么人们补充维生素D3将会大大保持自身的健康程度。
<br/><strong>编译自</strong><br/>
：<a href="http://www.sciencedaily.com/releases/2012/05/120531102338.htm">http://www.sciencedaily.com/releases/2012/05/120531102338.htm</a>
<div id="ztload">
<div>
<div>
<img src="http://www.bioon.com/biology/UploadFiles/201206/2012060312130972.jpg" alt="" width="113" height="149" border="0" />
<a title="" href="http://dx.doi.org/doi:10.3945/ajcn.111.031070" target="_blank">doi:10.3945/ajcn.111.031070</a>
PMC:
PMID:
</div>
<div>
<br/><strong>Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis1,2,3</strong><br/>
Laura Tripkovic, Helen Lambert, Kathryn Hart, Colin P Smith, Giselda Bucca, Simon Penson, Gemma Chope, Elina Hyppönen, Jacqueline Berry, Reinhold Vieth, and Susan Lanham-New
Background: Currently, there is a lack of clarity in the literature as to whether there is a definitive difference between the effects of vitamins D2 and D3 in the raising of serum 25-hydroxyvitamin D [25(OH)D]. Objective: The objective of this article was to report a systematic review and meta-analysis of randomized controlled trials (RCTs) that have directly compared the effects of vitamin D2 and vitamin D3 on serum 25(OH)D concentrations in humans. Design: The ISI Web of Knowledge (January 1966 to July 2011) database was searched electronically for all relevant studies in adults that directly compared vitamin D3 with vitamin D2. The Cochrane Clinical Trials Registry, International Standard Randomized Controlled Trials Number register, and clinicaltrials.gov were also searched for any unpublished trials. Results: A meta-analysis of RCTs indicated that supplementation with vitamin D3 had a significant and positive effect in the raising of serum 25(OH)D concentrations compared with the effect of vitamin D2 (P = 0.001). When the frequency of dosage administration was compared, there was a significant response for vitamin D3 when given as a bolus dose (P = 0.0002) compared with administration of vitamin D2, but the effect was lost with daily supplementation. Conclusions: This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3 could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.
<div><br/>来源：生物谷 </div>
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