Arch Gen Psychiatry：基底细胞癌风险与早期生活压力有关

早期生活陷入亲子关系困境的人在过去一年有严重生活困扰的话可能会罹患一种最常见的皮肤癌——基底细胞癌（BCC）。这项研究发表在<em>Archives of General Psychiatry</em>杂志上。

文章背景资料指出，压力事件和由此产生的负面情绪可以引发人体的免疫系统功能障碍，带来临床症状的重大变化，影响基底细胞癌以及病情的发展。童年暴晒于太阳下，白皙的皮肤类型和男性性别是基底细胞癌的第一危险因素，但研究人员强调但其该类型实肿瘤不只与这些危险因素有关。

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基底细胞癌患者体内免疫系统对肿瘤细胞起着负面突出作用，因为肿瘤细胞具有免疫原性，基底细胞癌不像其他许多常见的癌症，不会表现出同样的免疫系统反应，同时研究还发现患者心里压力可能对肿瘤的发生发展也发挥重要作用。

哥伦布俄亥俄州州立大学医学中心Christopher P. Fagundes博士他的团队考察了48男和43女，年龄在23岁至92岁之间的人，这些人早期都患有基底细胞癌，研究人员评估了这些人及其子女的最近生活状况、抑郁症和mRNA（信使RNA）的情况。

我们的研究结果表明基底细胞癌患者在过去一年中经历了严重的应激，那些经历母亲或父亲的情感虐待的孩子更可能有较差的免疫反应，表现为CD2 5、CD3ε、ICAM-1和CD68的mRNA的表达水平较低。研究人员得出结论：我们的研究数据显示基底细胞癌的风险与早期生活压力有关。 
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<img src="http://www.bioon.com/biology/UploadFiles/201206/2012061320365968.png" alt="" width="115" height="150" border="0" />

<a title="" href="http://dx.doi.org/10.1001/archgenpsychiatry.2011.1535" target="_blank">doi:10.1001/archgenpsychiatry.2011.1535</a>
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<br/><strong>NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function </strong><br/>


Christopher P. Fagundes, PhD; Ronald Glaser, PhD; Sheri L. Johnson, PhD; Rebecca R. Andridge, PhD; Eric V. Yang, PhD; Michael P. Di Gregorio, MS; Min Chen, MS; David R. Lambert, MD; Scott D. Jewell, MD; Mark A. Bechtel, MD; Dean W. Hearne, MD; Joel B. Herron, MD; Janice K. Kiecolt-Glaser, PhD

<br/><strong>Context</strong><br/>
Child emotional maltreatment can result in lasting immune dysregulation that may be heightened in the context of more recent life stress. Basal cell carcinoma (BCC) is the most common skin cancer, and the immune system plays a prominent role in tumor appearance and progression.

<br/><strong>Objective</strong><br/>
To address associations among recent severe life events, childhood parental emotional maltreatment, depression, and messenger RNA (mRNA) coding for immune markers associated with BCC tumor progression and regression.

<br/><strong>Design</strong><br/>
We collected information about early parent-child experiences, severe life events in the past year as assessed by the Life Events and Difficulties Schedule, depression, and mRNA for immune markers associated with BCC tumor progression and regression from patients with BCC tumors.

<br/><strong>Setting</strong><br/>
University medical center.

<br/><strong>Participants</strong><br/>
Ninety-one patients with BCC (ages, 23-92 years) who had a previous BCC tumor.

<br/><strong>Main Outcome Measures</strong><br/>
The expression of 4 BCC tumor mRNA markers (CD25, CD3ϵ, intercellular adhesion molecule 1, and CD68) that have been linked to BCC tumor progression and regression were assessed in BCC tumor biopsy specimens.

<br/><strong>Results</strong><br/>
Both maternal and paternal emotional maltreatment interacted with the occurrence of severe life events to predict the local immune response to the tumor (adjusted <em>P</em> = .009 and <em>P</em> = .03, respectively). Among BCC patients who had experienced a severe life event within the past year, those who were emotionally maltreated by their mothers (<em>P</em> = .007) or fathers (<em>P</em> = .02) as children had a poorer immune response to the BCC tumor. Emotional maltreatment was unrelated to BCC immune responses among those who did not experience a severe life event. Depressive symptoms were not associated with the local tumor immune response.

<br/><strong>Conclusions</strong><br/>
Troubled early parent-child relationships, in combination with a severe life event in the past year, predicted immune responses to a BCC tumor. The immunoreactivity observed in BCCs and the surrounding stroma reflects an anti–tumor-specific immune response that can be altered by stress.

<br/>来源：生物谷 

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