Breast Cancer Res Treat：睡眠不足易导致乳腺癌更具侵略性

缺乏睡眠与乳腺癌更具侵袭性存在联系，据一项新的发表在八月<em>Breast Cancer Research and Treatment</em>杂志上的研究证实。

该项研究在Cheryl Thompson博士的带领下，首次证实睡眠不足和肿瘤的更具侵略性和癌症复发有关。该研究小组分析了412名绝经后乳腺癌患者，在研究开始时所有患者均被招募进行诊断，并调查她们在过去两年内的平均睡眠时间。

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研究人员发现，平均每晚睡眠6小时或更少的女性乳腺癌的诊断有较高的安可待(Oncotype DX)复发分数。 安可待(Oncotype DX)是乳癌肿瘤基因分子检测项目，主要是检测乳癌肿瘤组织中21个不同基因的表现。

凯斯西储大学医学助理教授Thompson博士说：这是首次有研究表明，与睡眠时间更长的女性相比，那些经常睡眠时间不足的妇女更有可能发展患有更具侵袭性的乳癌。 我们发现每晚睡眠时间少和复发得分高有很强的相关性，特别是对那些绝经后乳腺癌患者来说。这表明，缺乏充足的睡眠可能会导致肿瘤更具侵略性，但需要做更多的研究来验证这一发现，并开展相关研究来了解这种关联的原因。

凯斯西储大学医学院流行病学和生物统计学医学博士Li Li说：睡眠时间短是危害公众健康的主要原因之一，这会导致肥胖、糖尿病和心脏疾病等问题。通过有效干预来增加睡眠时间，提高睡眠质量来降低乳腺癌发展成成更具侵袭性以及降低复发的风险可能是有效的手段之一。
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<a title="" href="http://dx.doi.org/10.1007/s10549-012-2144-z" target="_blank">doi:10.1007/s10549-012-2144-z</a>
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<br/><strong>Association of sleep duration and breast cancer OncotypeDX recurrence score</strong><br/>


Cheryl L. Thompson, Li Li

Shorter duration of sleep has been associated with risk of a number of medical conditions, including breast cancer. However, no prior study has investigated the relationship of average sleep duration before diagnosis and cancer aggressiveness. OncotypeDX is a widely utilized test to guide treatment in early stage hormone receptor positive breast cancer by predicting likelihood of recurrence. We reviewed medical records from ER+ early stage breast cancer patients participating in a case–control study for availability of OncotypeDX scores. All patients in the parent study were recruited at diagnosis and asked about average sleep duration in the 2 years before diagnosis. We analyzed data from 101 breast cancer patients with available OncotypeDX recurrence scores to test the hypothesis that shorter sleep is associated with greater likelihood of recurrence. We found that OncotypeDX recurrence scores were strongly correlated with average hours of sleep per night before breast cancer diagnosis, with fewer hours of sleep associated with a higher (worse) recurrence score (<em>R</em> = −0.30, <em>p</em> = 0.0031). This correlation was limited to post-menopausal breast cancer patients only (<em>R</em> = −0.41, <em>p</em> = 0.0011, for postmenopausal patients; <em>R</em> = −0.05, <em>p</em> = 0.80 for pre-menopausal patients). This association remains statistically significant after adjustment for age, physical activity, smoking status, and body mass index in the entire study sample (<em>p</em> = 0.0058) as well as in postmenopausal patients (<em>p</em> = 0.0021). This is the first study to suggest that women who routinely sleep fewer hours may develop more aggressive breast cancers compared with women who sleep longer hours.

<br/>来源：生物谷

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