新浪登录
腾讯登录CEBP:HPV DNA甲基化是预测宫颈癌的潜在标志物
| 导读 | <a href="http://img.360zhyx.com/uploads/2012/10/未命名2.jpg"><img class="aligncenter size-full wp-image-5066" title="未命名" src="http://img.360zhyx.com/uploads/2... |
<a href="http://img.360zhyx.com/uploads/2012/10/未命名2.jpg"><img class="aligncenter size-full wp-image-5066" title="未命名" src="http://img.360zhyx.com/uploads/2012/10/未命名2.jpg" alt="" width="136" height="180" /></a>
HPV感染在全球广泛流行，通常在数年内可被机体清除，只有极少部分的病例出现癌变。有多篇研究指出，HPV DNA甲基化可用于预测病人的CIN2+，如发现了L1基因CpG位置的甲基化和CIN2+存在关联。该综述讨论了目前对于HPV DNA甲基化的认识，并建议以后的研究可集中探究关于HPV DNA甲基化的预测意义<!--more-->
<br/><strong>附参考文献</strong><br/>
Human Papillomavirus DNA Methylation as a Potential Biomarker for Cervical Cancer
Sexually transmitted carcinogenic Human Papillomavirus (HPV) infections are extraordinarily prevalent worldwide. However, most incident HPV infections clear within a few years, whereas a small minority persists to invasive cancer. Recent studies indicate that detection of methylated viral DNA may distinguish women with cervical intraepithelial neoplasia grade 2+ (CIN2+) from those with a carcinogenic HPV type infection that shows no evidence of CIN2+. Several studies have reported a positive association between methylation of CpG sites in the L1 gene and CIN2+, while there are inconclusive results regarding methylation of CpG sites in the Upstream Regulatory Region (URR). In this review, we summarize the current state of knowledge on HPV DNA methylation in cervical carcinogenesis, and discuss the merits of different methods used to measure HPV DNA methylation. To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women.
文章链接：<a href="http://cebp.aacrjournals.org/content/early/2012/10/03/1055-9965.EPI-12-0905.abstract">http://cebp.aacrjournals.org/content/early/2012/10/03/1055-9965.EPI-12-0905.abstract</a>
<br/>来源：医学专业新闻
HPV感染在全球广泛流行，通常在数年内可被机体清除，只有极少部分的病例出现癌变。有多篇研究指出，HPV DNA甲基化可用于预测病人的CIN2+，如发现了L1基因CpG位置的甲基化和CIN2+存在关联。该综述讨论了目前对于HPV DNA甲基化的认识，并建议以后的研究可集中探究关于HPV DNA甲基化的预测意义<!--more-->
<br/><strong>附参考文献</strong><br/>
Human Papillomavirus DNA Methylation as a Potential Biomarker for Cervical Cancer
Sexually transmitted carcinogenic Human Papillomavirus (HPV) infections are extraordinarily prevalent worldwide. However, most incident HPV infections clear within a few years, whereas a small minority persists to invasive cancer. Recent studies indicate that detection of methylated viral DNA may distinguish women with cervical intraepithelial neoplasia grade 2+ (CIN2+) from those with a carcinogenic HPV type infection that shows no evidence of CIN2+. Several studies have reported a positive association between methylation of CpG sites in the L1 gene and CIN2+, while there are inconclusive results regarding methylation of CpG sites in the Upstream Regulatory Region (URR). In this review, we summarize the current state of knowledge on HPV DNA methylation in cervical carcinogenesis, and discuss the merits of different methods used to measure HPV DNA methylation. To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women.
文章链接：<a href="http://cebp.aacrjournals.org/content/early/2012/10/03/1055-9965.EPI-12-0905.abstract">http://cebp.aacrjournals.org/content/early/2012/10/03/1055-9965.EPI-12-0905.abstract</a>
<br/>来源：医学专业新闻
还没有人评论，赶快抢个沙发