Eur J Endocrinol：成长环境和两个EDCs对IPP的发病可能存在影响

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<a title="成长环境因素与IPP的回归分析结果" href="http://img.dxycdn.com/cms/upload/userfiles/image/2012/05/10/1336626888.jpg" rel="fancy_group"><img src="http://img.dxycdn.com/cms/upload/userfiles/image/2012/05/10/1336626888_small.jpg" alt="" /></a>
<br/><strong>成长环境因素与IPP的回归分析结果</strong><br/>


特发性性早熟(IPP)的发病率可能处于上升趋势。但IPP的病因和危险因素尚不清楚。安徽医科大学第一附属医院儿科的研究人员进行一个研究，评估成长环境和两个环境内分泌干扰物(EDCs)：玉米烯酮(ZEA) 和1,1-二氯-2，2，二乙烯(p,p'-DDE)对IPP患者的影响。该研究发表在Eur J Endocrinol杂志上。

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这是一个病例对照研究，研究纳入了78名诊断为IPP的患者和100名经年龄和性别匹配的对照儿童。设计调查问卷以收集所有受试者成长环境和血清ZEB和p,p'-DDE的数据。分析成长环境、两个EDCs以及成长环境和ECDs之间的生物相互作用。

研究发现，在成长环境的诸多因素中，胎龄小、母亲在妊娠期患有身体疾病、母亲初潮年龄较早、同级亲属有早熟情况以及在4至6岁年龄段父亲缺失均为IPP患儿的危险因素(P&lt;0.05)。IPP组血清ZEA分泌、ZEA和p,p'-DDE阳性率显著高于对照组(P&lt;0.05)。成长环境和ZEA存在生物相互作用(由相互作用引起的相对过剩风险=34.562, 相互作用引起的可归因比例=0.745, 协同指数=4.193)。

研究结果显示成长环境和两个EDCs对IPP的发病可能存在影响。另外，成长环境和ZEA之间的生物相互作用可能会增加IPP的发病风险。
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<h3>Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty.</h3>
Eur J Endocrinol 2012;1665:803-9

Deng F Tao FB Liu DY Xu YY Hao JH Sun Y Su PY

Department of Pediatrics, First Affiliated Hospital, Anhui Medical University, Hefei, China.

<br/><strong>Abstract</strong><br/>

The incidence of idiopathic precocious puberty (IPP) might have an increasing trend. But the causes and risk factors of IPP are unknown. The objective of our study is to evaluate the effects of growth environments and two environmental endocrine disruptors (EDCs), zearalenone (ZEA), and 1,1-dichloro-2,2,bisethylene (p,p'-DDE), on patients with IPP. Case-control study. The study consisted of 78 IPP patients at diagnosis and 100 control children matched for age and sex. A questionnaire was designed to collect data on growth environments, and serum ZEA and p,p'-DDE were tested in all subjects. We analyzed data on growth environments, two EDCs, and biological interaction between growth environments and EDCs. In growth environments, small for gestational age, maternal physical disease during pregnancy, early maternal menarche, early puberty of same-degree relatives, and father's absence in 4- to 6-year olds were risk factors for children with IPP (P&amp;lt;0.05). Serum ZEA concentration, ZEA, and p,p'-DDE-positive rates in the IPP group were significantly higher than those in the control group (P&amp;lt;0.05). There was a biological interaction between growth environments and ZEA (relative excess risk due to interaction=34.562, attributable proportion due to interaction =0.745, synergy index =4.193). Results suggest possible effects of growth environments and two EDCs on the development of IPP. In addition, growth environments and ZEA have biological interaction that might increase the risk of developing IPP.

<br/>来源：丁香园

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