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腾讯登录Nature:趋化因子CXCL10调节T细胞的新运动模式
| 导读 | <div id="region-column1and2-layout2">趋化因子在调节T细胞免疫功能中发挥重要作用。5月27日<em>Nature</em>杂志在线发表了Tajie H. Harris等的研究论文，进一步揭示了趋化因子CXCL10调节CD8+T细胞功能的机制，并发现了此类细胞新的运动方式。</div>
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<div id="region-column1and2-layout2">趋化因子在调节T细胞免疫功能中发挥重要作用。5月27日<em>Nature</em>杂志在线发表了Tajie H. Harris等的研究论文，进一步揭示了趋化因子CXCL10调节CD8+T细胞功能的机制，并发现了此类细胞新的运动方式。</div>
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利用多光子显微镜技术，研究者在大脑慢性感染弓形虫的小鼠模型中发现，CXCL10通过两种不同的方式增强T细胞的功能：其一，保持效应性T细胞在大脑中的数目；其二，加快此类细胞的平均迁徙速度。
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令人惊讶的是，CD8+T细胞在大脑内迁徙过程中的运动模式不是Brownian式的而是Lévy式的。据这项研究模型，Lévy式运动模式大大提高了T细胞发现稀有目标的效率，比Brownian模式增加了一个数量级。CD8+T细胞的运动行为方式类似于贻贝、海洋捕食者及猴子，而CXCL10帮助CD8+T细胞加快了找到稀有目标的速度。
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<img src="http://www.bioon.com/biology/UploadFiles/201206/2012060314345068.jpg" alt="" width="113" height="149" border="0" hspace="0" />
<a title="" href="http://dx.doi.org/10.1016/j.cell.2011.10.017" target="_blank">doi:</a><a title="" href="http://dx.doi.org/10.1038/nature11098" target="_blank">10.1016/j.cell.2011.10.017</a>
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<div><br/><strong>Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells</strong><br/>
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<div>Tajie H. Harris, Edward J. Banigan,David A. Christian,et al</div>
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<div>Chemokines have a central role in regulating processes essential to the immune function of T cells1, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effector T-cell population in the brain and speeds up the average migration speed without changing the nature of the walk statistics. Notably, these statistics are not Brownian; rather, CD8+ T-cell motility in the brain is well described by a generalized Lévy walk. According to our model, this unexpected feature enables T cells to find rare targets with more than an order of magnitude more efficiency than Brownian random walkers. Thus, CD8+ T-cell behaviour is similar to Lévy strategies reported in organisms ranging from mussels to marine predators and monkeys and CXCL10 aids T cells in shortening the average time taken to find rare targets.</div>
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<div> <br/>来源：生物谷 </div>
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<div id="region-column1and2-layout2">
利用多光子显微镜技术，研究者在大脑慢性感染弓形虫的小鼠模型中发现，CXCL10通过两种不同的方式增强T细胞的功能：其一，保持效应性T细胞在大脑中的数目；其二，加快此类细胞的平均迁徙速度。
<!--more-->
令人惊讶的是，CD8+T细胞在大脑内迁徙过程中的运动模式不是Brownian式的而是Lévy式的。据这项研究模型，Lévy式运动模式大大提高了T细胞发现稀有目标的效率，比Brownian模式增加了一个数量级。CD8+T细胞的运动行为方式类似于贻贝、海洋捕食者及猴子，而CXCL10帮助CD8+T细胞加快了找到稀有目标的速度。
<div id="ztload">
<div>
<div>
<img src="http://www.bioon.com/biology/UploadFiles/201206/2012060314345068.jpg" alt="" width="113" height="149" border="0" hspace="0" />
<a title="" href="http://dx.doi.org/10.1016/j.cell.2011.10.017" target="_blank">doi:</a><a title="" href="http://dx.doi.org/10.1038/nature11098" target="_blank">10.1016/j.cell.2011.10.017</a>
PMC:
PMID:
</div>
<div><br/><strong>Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells</strong><br/>
</div>
<div> </div>
<div>Tajie H. Harris, Edward J. Banigan,David A. Christian,et al</div>
<div> </div>
<div>Chemokines have a central role in regulating processes essential to the immune function of T cells1, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effector T-cell population in the brain and speeds up the average migration speed without changing the nature of the walk statistics. Notably, these statistics are not Brownian; rather, CD8+ T-cell motility in the brain is well described by a generalized Lévy walk. According to our model, this unexpected feature enables T cells to find rare targets with more than an order of magnitude more efficiency than Brownian random walkers. Thus, CD8+ T-cell behaviour is similar to Lévy strategies reported in organisms ranging from mussels to marine predators and monkeys and CXCL10 aids T cells in shortening the average time taken to find rare targets.</div>
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<div> <br/>来源：生物谷 </div>
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