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腾讯登录催产素受体基因的变异与婚姻稳定性及人类社会性有关
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<p style="text-align: left;" align="center">婚姻稳定性也与基因相关，这个基因就是催产素受体基因OXTR。它里面的两个位点关联着我们的婚姻幸福，其中一个是女性特有，其能影响社会行为，并一定程度能预测婚姻的稳定性。这项研究分析了五千多个瑞典人，大部分是双胞胎。</p>
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<p style="text-align: left;" align="center">婚姻稳定性也与基因相关，这个基因就是催产素受体基因OXTR。它里面的两个位点关联着我们的婚姻幸福，其中一个是女性特有，其能影响社会行为，并一定程度能预测婚姻的稳定性。这项研究分析了五千多个瑞典人，大部分是双胞胎。</p>
<p style="text-align: left;" align="center"><!--more--></p>
<h1>Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior</h1>
<p align="left">Background</p>
<p align="left">In specific vole and primate species the neuropeptide oxytocin plays a central role in the regulation of pair-bonding behavior. Here we investigate the extent to which genetic variants in the oxytocin receptor gene (<em>OXTR</em>) are associated with pair-bonding and related social behaviors in humans.</p>
<p align="left">Methods</p>
<p align="left">We first genotyped twelve single nucleotide polymorphisms (SNPs) in the TOSS (Twin and Offspring Study in Sweden) (<em>n</em> = 2309) and the TCHAD (Swedish Twin Study of Child and Adolescent Development) (<em>n</em> = 1240), comprising measures of self-reported pair-bonding behavior. In the TOSS sample we further investigated one of the SNPs for measures of marital status and quality. Moreover, in the TCHAD sample we explored the longitudinal relationship between precursors of pair-bonding during childhood and subsequent behavior in romantic relationships. Finally, in the TCHAD study and in the Child and Adolescent Twin Study of Sweden (CATSS) (<em>n</em> = 1771), the association between the same SNP and childhood behaviors was investigated.</p>
<p align="left">Results</p>
<p align="left">One SNP (rs7632287) in <em>OXTR</em> was associated with traits reflecting pair-bonding in women in the TOSS and TCHAD samples. In girls the rs7632287 SNP was further associated with childhood social problems, which longitudinally predicted pair-bonding behavior in the TCHAD sample. This association was replicated in the CATSS sample in which an association between the same SNP and social interaction deficit symptoms from the autism spectrum was detected.</p>
<p align="left">Conclusion</p>
<p align="left">These results suggest an association between variation in <em>OXTR</em> and human pair-bonding and other social behaviors, possibly indicating that the well-described influence of oxytocin on affiliative behavior in voles could also be of importance for humans.</p>
原文链接：http://www.biologicalpsychiatryjournal.com/article/S0006-3223(11)00860-2/abstract
<p style="text-align: left;" align="center">婚姻稳定性也与基因相关，这个基因就是催产素受体基因OXTR。它里面的两个位点关联着我们的婚姻幸福，其中一个是女性特有，其能影响社会行为，并一定程度能预测婚姻的稳定性。这项研究分析了五千多个瑞典人，大部分是双胞胎。</p>
<p style="text-align: left;" align="center"><!--more--></p>
<h1>Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior</h1>
<p align="left">Background</p>
<p align="left">In specific vole and primate species the neuropeptide oxytocin plays a central role in the regulation of pair-bonding behavior. Here we investigate the extent to which genetic variants in the oxytocin receptor gene (<em>OXTR</em>) are associated with pair-bonding and related social behaviors in humans.</p>
<p align="left">Methods</p>
<p align="left">We first genotyped twelve single nucleotide polymorphisms (SNPs) in the TOSS (Twin and Offspring Study in Sweden) (<em>n</em> = 2309) and the TCHAD (Swedish Twin Study of Child and Adolescent Development) (<em>n</em> = 1240), comprising measures of self-reported pair-bonding behavior. In the TOSS sample we further investigated one of the SNPs for measures of marital status and quality. Moreover, in the TCHAD sample we explored the longitudinal relationship between precursors of pair-bonding during childhood and subsequent behavior in romantic relationships. Finally, in the TCHAD study and in the Child and Adolescent Twin Study of Sweden (CATSS) (<em>n</em> = 1771), the association between the same SNP and childhood behaviors was investigated.</p>
<p align="left">Results</p>
<p align="left">One SNP (rs7632287) in <em>OXTR</em> was associated with traits reflecting pair-bonding in women in the TOSS and TCHAD samples. In girls the rs7632287 SNP was further associated with childhood social problems, which longitudinally predicted pair-bonding behavior in the TCHAD sample. This association was replicated in the CATSS sample in which an association between the same SNP and social interaction deficit symptoms from the autism spectrum was detected.</p>
<p align="left">Conclusion</p>
<p align="left">These results suggest an association between variation in <em>OXTR</em> and human pair-bonding and other social behaviors, possibly indicating that the well-described influence of oxytocin on affiliative behavior in voles could also be of importance for humans.</p>
原文链接：http://www.biologicalpsychiatryjournal.com/article/S0006-3223(11)00860-2/abstract
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