维生素D的缺乏或增加心脏病风险

<a href="http://img.360zhyx.com/uploads/2012/09/g3_6432975.jpg"><img class="aligncenter size-full wp-image-4289" title="g3_6432975" src="http://img.360zhyx.com/uploads/2012/09/g3_6432975.jpg" alt="" width="490" height="700" /></a>

近日，一项来自哥本哈根大学大学等机构的研究证明，<span style="text-decoration: underline;">低水平的维生素D和高风险的心脏病发作以及早逝直接相关</span>，这项研究对超过10，000个丹麦人就行了相关的研究，相关研究成果刊登在了近日的国际杂志<em>journal Arteriosclerosis，Thrombosis and Vascular Biology</em>上。<!--more-->

一般认为，维生素D的缺乏和骨质健康有密切关系。然而，很多研究揭示了，<span style="text-decoration: underline;">低水平的维生素D和高风险的缺血性心脏病明显相关。也有研究表明维生素D的缺乏可以使得血压升高，高血压可增加心脏病发作风险。</span>

研究者Peter博士表示，在本项研究中，我们检测了低水平维生素D和缺血性心脏病以及早逝的关系，我们观察到，相比最优水平的维生素D，低水平的维生素D可增加缺血性心脏病风险达40%，心脏病发作风险增加64%，早逝风险增加57%，而因为心脏病死亡的风险增高不低于81%。

如今，研究者试图深入研究确定是否低水平的维生素D和高风险心脏病之间的关联是否是一种真正的因果关系。研究者Borge Nordestgaard表示，最简单直接的方法就是通过晒太阳来获得维生素D，也有充足证据表明合理的太阳照射是有益的，但是人们也应该避免受到灼伤，这将会增加皮肤癌的风险。除此之外，合理的补充维生素D的饮食也很重要，其对于预防心脏疾病以及早逝也很关键。

编译自：<a title="" href="http://medicalxpress.com/news/2012-09-vitamin-d-deficiency-heart-disease.html" target="_blank">Vitamin D deficiency increases risk of heart disease</a>
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<a title="" href="http://dx.doi.org/doi:10.1161/%E2%80%8BATVBAHA.112.248039" target="_blank">doi:10.1161/ATVBAHA.112.248039</a>
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<br/><strong>25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death Population-Based Study and Meta-Analyses of 18 and 17 Studies</strong><br/>


Peter Brøndum-Jacobsen, Marianne Benn, Gorm B. Jensen, Børge G. Nordestgaard

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Objective—We tested the hypothesis that reduced plasma 25-hydroxyvitamin D associates with increased risk of ischemic heart disease, myocardial infarction, and early death. Methods and Results—We measured baseline plasma 25-hydroxyvitamin D in 10 170 women and men from the Danish general population without vitamin D–fortified food. During 29 years of follow-up, 3100 persons developed ischemic heart disease, 1625 myocardial infarction, and 6747 died. Decreasing plasma 25-hydroxyvitamin D levels were associated with increasing risk of ischemic heart disease, myocardial infarction, and early death as a function of seasonally adjusted percentile categories (P for trend, 2×10−5–3×10–53). Comparing individuals with plasma 25-hydroxyvitamin D levels at the 1st to 4th percentile with individuals with levels at the 50th to 100th percentile, the multivariable adjusted risk was increased by 40% (95% CI, 14%–72%) for ischemic heart disease, by 64% (25%–114%) for myocardial infarction, by 57% (38%–78%) for early death, and by 81% (40%–135%) for fatal ischemic heart disease/myocardial infarction. In the meta-analyses of 18 and 17 studies, risk of ischemic heart disease and early death were increased by 39% (25%–54%) and 46% (31%–64%) for lowest versus highest quartile of 25-hydroxyvitamin D level. Conclusion—We observed increasing risk of ischemic heart disease, myocardial infarction, and early death with decreasing plasma 25-hydroxyvitamin D levels. These findings were substantiated in meta-analyses.

<br/>来源：生物谷

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