Ann Oncol：喝咖啡或降低前列腺癌风险

    瑞典一项研究表明，咖啡饮用量与局部前列腺癌风险呈负相关性。这种负相关性在超重和肥胖的男性中更为明显。该研究论文3月18日在线发表于《肿瘤学年鉴》（Ann Oncol）。

　　该研究从1998年1月至2010年12月对44613名45～79岁的瑞典男性进行随访，以获取局部（n=2368）、晚期（n=918）和致命性（n=515）前列腺癌的患病率数据。

　　研究评估了咖啡饮用量与局部、晚期及致命性前列腺癌风险的相关性，并评估了体质指数（BMI）对研究结果可能造成的影响。

　　结果显示，每日咖啡饮用量每增加1杯与局部前列腺癌风险降低3％相关，与晚期和致命性前列腺癌风险降低2％呈不显著的相关性。

　　研究还发现，对于局部前列腺癌患者，超重和肥胖（BMI≥25 kg/m2）者的上述负相关性高于正常体重（BMI＜25 kg/m2）者。

原文链接：

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Coffee consumption and risk of localized, advanced and fatal prostate cancer: a population-based prospective study

Abstract

Background The epidemiological evidence on possible relationships between coffee consumption and prostate cancer (PCa) risk by subtype of the disease (localized, advanced) and fatal PCa risk is limited.

Materials

and methods A population-based cohort of 44 613 Swedish men aged 45–79 years was followed up from January 1998 through December 2010 for incidence of localized (n = 2368), advanced (n = 918) and fatal (n = 515) PCa. We assessed the associations between coffee consumption and localized, advanced and fatal PCa risk using competing-risk regressions. We examined possible effect modification by body mass index (BMI).

Results

For localized PCa, each one cup increase in daily coffee consumption was associated with a 3% reduced risk [sub-hazard ratio (SHR) = 0.97, 95% confidence interval (CI) = 0.95–0.99]. For advanced and fatal PCa, we found a non-significant inverse association; each one cup increase was associated with a 2% reduced risk of advanced [SHR (95% CI) = 0.98 (0.95–1.02)] and fatal PCa [SHR (95% CI) = 0.98 (0.93–1.03)]. We observed evidence of effect modification by BMI for localized PCa (Pinteraction = 0.03); the inverse association was stronger among overweight and obese men (BMI ≥ 25 kg/m2) compared with normal-weight men (BMI < 25 kg/m2).

Conclusions

We observed a clear inverse association between coffee consumption and risk of localized PCa, especially among overweight and obese men.

来源：医学论坛网