Hypertension：心血管危险因素或可诱发胎盘早剥

       荷兰和英国一项联合研究表明，确定性心血管危险因素可诱发胎盘早剥以及后期早发心血管疾病形成。论文4月8在线发表于《高血压》（Hypertension）。

　　此项研究共纳入75例伴有胎盘早剥病史的女性以及79例无事件妊娠对照女性，并在产后6至9个月比较了常见心血管危险因素的存在情况。依据并发高血压病存在与否对数据加以分成，并对潜在混淆因素进行更深入校正。

　　结果显示，与无事件妊娠的对照者相比，伴胎盘早剥病史者的平均收缩压、体重指数、空腹血糖、C反应蛋白、总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇均显著升高。在亚组分析中，除低密度脂蛋白胆固醇以及收缩压和舒张压相关性之外，所有差异在仅伴胎盘早剥病史女性（即无并发妊娠高血压者）中依然保持显著。

原文链接：

---

Maternal Cardiovascular Risk Profile After Placental Abruption.

Abstract
The prevalence of premature cardiovascular diseases (CVD) is increased in women with a history of maternal placental syndromes, including pregnancy-associated hypertensive disorders (eg, preeclampsia), fetal growth restriction, and placental abruption. Whereas previous studies have shown a high prevalence of CVD risk factors after pregnancies complicated by preeclampsia, this has not been studied for women with a history of placental abruption. To explore the association of placental abruption with CVD risk factors after delivery, we compared 75 women with a history of placental abruption with a control group of 79 women with uneventful pregnancies at 6 to 9 months postpartum for the presence of common CVD risk factors. In a subanalysis, data were stratified according to the presence or absence of concomitant hypertensive disease and further adjusted for potential confounders. Women with previous placental abruption had significantly higher mean systolic blood pressure, body-mass index, fasting blood glucose, C-reactive protein, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol as compared with controls with only uneventful pregnancies. In the subanalysis, all differences remained significant for women with a history of placental abruption only (ie, without concomitant gestational hypertension), except for the associations with low-density lipoprotein-cholesterol and diastolic and systolic blood pressure. Most likely, the identified CVD risk factors predispose to placental abruption and development of premature CVD later in life.

关注转化医学网

---

【转化医学网 新浪微博：@转化医学网】
【转化医学网 公众微信账号：zhuanhuayixue】或扫描二维码关注微信

来源：医学论坛网