研究称口腔溃疡与智商下降有关

俄新社3月26日消息，美国研究者日前对曼哈顿北部1600多名年龄在69岁左右的居民进行了血样检测，发现血液中存在一些病毒可能导致智力、记忆力下降。

据报道，美国科学家发表于杂志《神经学》的文章称，疱疹病毒可导致嘴唇上出现小溃疡，这与其它类似感染一样，可能与智力问题有关。

美国神经学会新闻稿介绍，若在人的血液中发现大量抗体则表明人体被感染，即有可能患某种疾病。拿疱疹病毒来说，若血液中一类疱疹病毒数量较多，则易患认知性困难疾病。

纽约哥伦比亚大学医学中心的米拉·卡坦表示，疱疹病毒和认知困难之间的联系在女性中更为明显，尤其是受教育度不高，没有医保，不经常用脑的女性。

科学家表示，虽然还需要进一步的调查，但现在的结果已可帮助我们及时发现这种疾病，并降低患病风险。例如，我们可以通过加强记忆力训练，给孩子及时接种疫苗等办法来降低其出现几率。


原文链接：

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Infectious burden and cognitive function

Objective: We hypothesized that infectious burden (IB), a composite serologic measure of exposure to common pathogens (i.e., Chlamydia pneumoniae, Helicobacter pylori, cytomegalovirus, and herpes simplex virus 1 and 2) associated with vascular risk in the prospective Northern Manhattan Study (NOMAS), would also be associated with cognition.

Methods: Cognition was assessed using the Mini-Mental State Examination (MMSE) at enrollment and the modified Telephone Interview for Cognitive Status (TICS-m) at annual follow-up visits. Adjusted linear and logistic regressions were used to measure the association between IB index and MMSE. Generalized estimating equation models were used to evaluate associations with TICS-m and its change over time.

Results: Serologies and cognitive assessments were available in 1,625 participants of the NOMAS cohort. In unadjusted analyses, higher IB index was associated with worse cognition (change per standard deviation [SD] of IB for MMSE was −0.77, p < 0.0001, and for first measurements of TICS-m was −1.89, p < 0.0001). These effects were attenuated after adjusting for risk factors (for MMSE adjusted change per SD of IB = −0.17, p = 0.06, for TICS-m adjusted change per SD IB = −0.68, p < 0.0001). IB was associated with MMSE ≤24 (compared to MMSE >24, adjusted odds ratio 1.26 per SD of IB, 95% confidence interval 1.06–1.51). IB was not associated with cognitive decline over time. The results were similar when IB was limited to viral serologies only.

Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.


来源：环球网