新浪登录
腾讯登录Neurology：新影像技术加速多发性硬化症研究
| 导读 |
日前，加拿大英属哥伦比亚大学（UBC）该校科研人员开发出一种最新的核磁共振影像（MRI）技术，可以检测更加细微的多发性硬化症，为治疗提供了更新的手段。相关研究论文刊登在了近期出版的《神经病学》（Neurology）期刊上。
多发性硬化症发生，是当人的免疫细胞攻击髓磷脂，也就是环护神经纤维的阻隔层时，导致髓磷脂崩溃，阻遏神经元间的电信号传递，症... |
日前，加拿大英属哥伦比亚大学（UBC）该校科研人员开发出一种最新的核磁共振影像（MRI）技术，可以检测更加细微的多发性硬化症，为治疗提供了更新的手段。相关研究论文刊登在了近期出版的《神经病学》（Neurology）期刊上。
多发性硬化症发生，是当人的免疫细胞攻击髓磷脂，也就是环护神经纤维的阻隔层时，导致髓磷脂崩溃，阻遏神经元间的电信号传递，症状包括麻木、衰弱、失明、颤抖、头晕眼花和疲劳。
一直以来，分析MRI每秒回波数，被认为是确定人组织结构变化的灵敏手段，但计算可用的图形非常困难。新技术通过分析MRI扫描仪获取的电磁波频率，而非以往分析波形。UBC的科研人员和附属医院门诊医生用新、旧两种设备每月扫描一次，持续了半年，并分析了20位病患的核磁共振脑扫描频率。一旦髓磷脂出现组织损伤，传统核磁共振扫描仪会显示，基于频率的新型核磁共振扫描，早于传统扫描仪之前两个月发现了状况，精确分析组织损伤区域，发现频率发生了变化，即提前发现了组织损伤。
研究人员认为，由于新的核磁共振技术对病变反映更灵敏，据此可开展更为精细研究，如开发新药、更早确定治疗方案，减缓甚至阻止髓磷脂的崩溃。
原文链接：
Magnetic resonance frequency shifts during acute MS lesion formation
Objective: We investigated the evolution of new multiple sclerosis (MS) lesions over time using frequency shifts of the magnetic resonance resonance (MR) signal.
Methods: Twenty patients with relapsing-remitting MS were serially scanned for 6 months at 1-month intervals. Maps of MR frequency shifts were acquired using susceptibility-weighted imaging. New lesions were identified by enhancement with gadolinium (Gd).
Results: Forty new lesions were identified as areas of signal increase on Gd-enhanced scans. Up to 3 months before lesion appearance, the frequency in areas of future Gd enhancement was not detectably different from the frequency in normal-appearing white matter. Rapid increase in MR frequency was observed between 1 month before and 1 month after Gd enhancement. Two months postenhancement and later, the frequency stabilized and remained at a constantly increased level.
Conclusions: These findings suggest that an increase in MR frequency does not simply reflect blood-brain barrier disruption or edema; rather, it reflects a change of tissue architecture as a consequence of new lesion formation. The data demonstrate that the MR frequency of focal MS lesions is increased before the lesions appear on conventional MRI. Unlike many other advanced imaging techniques, the images for frequency mapping can be rapidly acquired at high spatial resolution and standardized on most clinical scanners.
来源：科技部
Methods: Twenty patients with relapsing-remitting MS were serially scanned for 6 months at 1-month intervals. Maps of MR frequency shifts were acquired using susceptibility-weighted imaging. New lesions were identified by enhancement with gadolinium (Gd).
Results: Forty new lesions were identified as areas of signal increase on Gd-enhanced scans. Up to 3 months before lesion appearance, the frequency in areas of future Gd enhancement was not detectably different from the frequency in normal-appearing white matter. Rapid increase in MR frequency was observed between 1 month before and 1 month after Gd enhancement. Two months postenhancement and later, the frequency stabilized and remained at a constantly increased level.
Conclusions: These findings suggest that an increase in MR frequency does not simply reflect blood-brain barrier disruption or edema; rather, it reflects a change of tissue architecture as a consequence of new lesion formation. The data demonstrate that the MR frequency of focal MS lesions is increased before the lesions appear on conventional MRI. Unlike many other advanced imaging techniques, the images for frequency mapping can be rapidly acquired at high spatial resolution and standardized on most clinical scanners.
来源：科技部
还没有人评论，赶快抢个沙发