NATURE：小分子物质促进期待造血干细胞大量增殖，有望取代骨髓移植

 一些小分子可以促进从脐带血中获得的干细胞的生长。而这些干细胞在将来可能用于某些血液癌症的治疗。

加拿大的蒙特利尔大学的Guy Sauvageau和他的同事们成功筛选出了一系列小分子物质，这些小分子物质能够促进人类脐带造血干细胞的繁殖，而这些造血干细胞能够长期的产生所有的血液细胞。这些分子同时能在移植小鼠中，能够引发脐带造血干细胞的增殖，产生全部种类的成熟的血细胞。

并且，作者认为，脐带造血干细胞能够替代现在供不应求的骨髓，进行移植，挽救白血病等病人的生命。

原文：

A group of small molecules can spur the growth of stem cells from umbilical cord blood. These could one day be used as transplants to treat, for example, certain blood cancers.

Guy Sauvageau at the University of Montreal in Canada and his colleagues screened a library of small molecules for ones that stimulate the proliferation of human cord-blood stem cells that drive the long-term production of all blood cells. They found one molecule that worked particularly well and synthesized an optimized version, UM171, that performed even better. This molecule triggered the expansion of cord-blood stem cells that, when transplanted into mice, generated the full array of mature blood cells.

Cord-blood stem cells could be an alternative to bone-marrow transplants, which are currently in short supply, the authors say.

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