J Agric Food Chem：紫檀芪或可作为治疗肥胖的潜在疗法

紫檀芪（Pterostilbene）是同白藜芦醇同属于一个家族的酚类化合物，其在多种食物中都存在但含量非常少；近日来自巴斯克地区大学（University of the Basque Country）的研究人员通过研究发现紫檀芪可以减少小鼠模型机体脂肪的堆积，其或许可以降低诸如糖尿病等疾病的风险，相关研究刊登于国际杂志Journal of Agricultural and Food Chemistry上。

肥胖是由一系列因子影响的慢性疾病，其通常被定义为体内脂肪的过度堆积，肥胖也是发达国家非常流行的一种代谢性疾病，其也是引发其它疾病，比如高血压、糖尿病等疾病的元凶。

传统抑制及治疗肥胖的准则包括低能量饮食及进行适量体力活动，然而这些策略的有效性非常有限，而且我们所认为的“成功”并没有达到我们想要的结果；这项研究中，研究人员表示，一种饮食中有用的成分，即紫檀芪或许为治疗肥胖提供了一定的希望。

紫檀芪是一种存在于许多食物和饮料中，含量非常少的化合物，目前对紫檀芪效应的研究非常少，而且研究者们主要进行其对癌症的效应研究；本文研究则是分析紫檀芪对肥胖小鼠模型的效应，在小鼠模型中，研究者发现紫檀芪可以切断小鼠的机体脂肪，减少小鼠机体脂肪组织中脂肪的合成并且增加肝脏中氧化作用。研究者表示，未来研究中我们将进行人体实验来评估紫檀芪的减肥效应，本文研究为后期我们开发抑制肥胖的新型疗法提供了一定的帮助和希望。（转化医学网360zhyx.com）
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Pterostilbene, a Dimethyl Ether Derivative of Resveratrol, Reduces Fat Accumulation in Rats Fed an Obesogenic Diet
J. Agric. Food Chem DOI: 10.1021/jf501318b
Saioa Gómez-Zorita †§, Alfredo Fernández-Quintela †§, Arrate Lasa †§, Leixuri Aguirre †§, Agnes M. Rimando #, and María P. Portillo *†§
The current study aimed to demonstrate the effects of pterostilbene in rats fed an obesogenic diet. For this purpose, pterostilbene was administered at doses of 15 mg/kg body weight/day (PT15 group) or 30 mg/kg body weight/day (PT30 group) for 6 weeks. Pterostilbene reduced adipose tissue mass −15.1% (PT15) and −22.9% (PT30). In this tissue, it decreased malic enzyme (−39.4 and −49.5% for PT15 and PT30 groups, respectively) and fatty acid synthase (−45 and −53.4% for PT15 and PT30) activities. Acetyl-CoA carboxylase activity was reduced and AMPK activity was increased only in the PT30 group. In the liver, pterostilbene (PT30) reduced malic enzyme (−29.5%) and glucose-6-P dehydrogenase (−43.2%) activities and increased carnitine palmitoyltransferase-1a (37.5%) and acyl-coenzyme A oxidase (42.5%) activities. This increased oxidative capacity was not associated with increased mitochondriogenesis. Among biochemical serum parameters, only insulin was modified by pterostilbene (−31.6%) in the PT15 group. The amounts of pterostilbene in serum and tissues from rats in the PT30 group were in not all cases 2-fold greater than those found in the PT15 group. In conclusion, pterostilbene shows antiobesity properties due, at least in part, to reduced lipogenesis in adipose tissue and increased fatty acid oxidation in liver.