睡眠呼吸暂停或损害2型糖尿病患者肾脏功能

  近日，在宾夕法尼亚会议中心举办的2014年美国肾脏病学会(American Society Of Nephrology)周上，来自南卡罗莱纳医科大学的研究者表示，睡眠呼吸暂停或可加速患肾病的糖尿病病人的肾脏功能的下降。
  2型糖尿病常常会引发慢性肾病（chronic kidney disease，CKD）的发生，由于阻塞性睡眠呼吸暂停在2型糖尿病患者中非常常见，因此研究人员想知道是否2型糖尿病患者个体的睡眠障碍在糖尿病和肾脏功能失调之间的关系中扮演着重要角色；
  因此研究人员Roberto Pisoni博士开展了这项研究，研究者以调查问卷的方式对56名糖尿病和CKD患者的信息进行分析，CKD患者进行了阻塞性睡眠呼吸暂停的筛查；结果显示，61%的患者调查问卷的分值都较高，相比低分值的个体来讲，这些个体的肾脏功能水平发生了明显的下降。
  本文研究显示，阻塞性睡眠呼吸暂停的高风险分值在糖尿病肾病的非透析CKD患者中非常常见，而且其和患者肾功能的快速缺失直接相关，利用这种简单的方法或可鉴别出处于高风险慢性肾病的患者。（转化医学网360zhyx.com）
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Type 2 diabetes often contributes to the development of chronic kidney disease (CKD). Because obstructive sleep apnea is common in patients with type 2 diabetes, investigators wonder whether disordered sleep might play a role in the link between diabetes and kidney dysfunction. To investigate, researchers led by Roberto Pisoni, MD (Medical University of South Carolina) analyzed information on 56 patients with diabetes and CKD who had undergone screening for obstructive sleep apnea through the use of a questionnaire.

The researchers found that 61% of patients had a high score on the questionnaire. These individuals had a significantly lower level of kidney function than those with a low score.

"This study shows that a high-risk score for obstructive sleep apnea is common in non-dialysis CKD patients with diabetic nephropathy and is associated with more rapid loss of renal function," the investigators concluded. "This simple approach identifies patients at higher risk of CKD progression."