JAMA：HIV阳性的成年个体听力或较差

  近日，发表于国际杂志JAMA Otolaryngology-Head & Neck Surgery上的一篇研究论文中，来自圣地亚哥州立大学的研究人员通过研究表示，相比未感染HIV的个体而言，HIV阳性的成年个体往往具有较差的低频听力或者高频听力。
  在高活性抗逆转录病毒疗法的时代，HIV和听力缺失之间的关系并没有得到很好地阐明，研究者Peter Torre III表示，文章中我们对262名男性（其中117名HIV阳性个体），134名女性（其中105名HIV阳性个体）进行研究，评估了这些个体机体的纯音听力阈值，其中参与男性个体的平均年龄在57岁左右，女性个体的平均年龄在48岁左右。
  研究结果显示，相比HIV阴性的成年个体而言，高频率的纯音平均值（HPTA）和低频率的纯音平均值（LPTA）在HIV阳性的成年个体中明显升高，而这项研究结果并不依赖个体长期暴露于抗逆转录病毒的疗法、CD4+细胞计数以及HIV病毒载量的测定之中。
  最后研究人员表示，据我们所知，本研究首次阐明了HIV阳性个体在整个频率范围内的听力都较差，尽管我们知道许多其它因子可以影响患者的听力；研究人员希望后期通过更为深入的研究来解析HIV阳性个体听力较差的原因，为改善患者的生活质量提供一定的帮助。（转化医学网360zhyx.com）
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Adults with the human immunodeficiency virus (HIV+) had poorer lower- and higher-frequency hearing than adults without HIV infection, according to a report published online by JAMA Otolaryngology-Head & Neck Surgery.
The relationship between HIV and hearing loss in the era of highly active antiretroviral therapy (HAART) has not been investigated thoroughly, according to the study background.
Peter Torre III, Ph.D., of San Diego State University, California, and coauthors evaluated pure-tone hearing thresholds among 262 men (117 HIV+) and 134 women (105 HIV+). The men had an average age of 57 years and the women were an average age of nearly 48.
The authors found that high-frequency pure-tone average (HPTA) and low-frequency (LPTA) were significantly higher (i.e. poorer hearing) for HIV+ adults compared with HIV- adults for the better ear. The results were independent of long-term exposure to antiretroviral medications, current CD4+ cell count and HIV viral load.
"To our knowledge, this is the first study to demonstrate that HIV+ individuals have poorer hearing across the frequency range after many other factors known to affect hearing have been controlled for," the study concludes.