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最新设备实现对心脏病的长效治疗

首页 » 研究 » 心血管 2015-01-08 转化医学网 赞(2)
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NuVascular科技与伍斯特理工学院及BioSurfaces公司合作推广BioGenerator干细胞临床应用设备。该设备应用了伍斯特成人骨髓细胞库产生的干细胞,这些细胞可以通过BioGenerator设备被附加到心脏壁或通过导管注入心肌组织。

  NuVascular科技与伍斯特理工学院及BioSurfaces公司合作推广BioGenerator干细胞临床应用设备。该设备应用了伍斯特成人骨髓细胞库产生的干细胞,这些细胞可以通过BioGenerator设备被附加到心脏壁或通过导管注入心肌组织。

  运行时,该设备通过静电泡将干细胞释放蛋白质和生长因子直接导入心脏,刺激心脏产生新细胞。在整个治疗过程中干细胞本身保持不变,并可随时通过外植体BioGenerator从患者体内移除。该设备有望成为心肌梗塞治疗领域的突破性设备,彻底解决目前绝大多数疗法只能轻微和暂时地对心机梗塞起到治疗作用的窘况。

  NuVascular科技创始人和首席技术官Matthew Phaneuf表示:“我们的纳米纤维支架将直接将外源干细胞植入患者心脏的受损区域,确保患者在干细胞治疗中获益。如果需要,这个支架也能阻止干细胞离开目标区域以及允许装置的移除。我们相信,我们的设备能提供一个微创、高效的心脏病治疗方法,并扭转目前心肌梗塞治疗领域的窘境,而不是提供一个通常伴随着并发症的临时解决方案。”(转化医学网360zhyx.com

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  NuVascular Technologies (Ashland, MA) has partnered with Worcester Polytechnic Institute and BioSurfaces, Inc. (Ashland, MA) to introduce the BioGenerator stem cell device for clinical applications. The device holds stem cells produced at Worcester from adult bone marrow cells. It can either be attached to the heart wall or injected into cardiac tissue via a catheter.
  The electrospun vesicle allows stem cells within to release proteins and growth factors directly into the heart to motivate production of new myocytes. The stem cells themselves stay put and can be removed at any time by explanting the BioGenerator. The hope is that the system will serve as a functional treatment option for hearts damaged by infarcts, eclipsing many current therapies that only marginally and temporarily address the problem.
  “Our nanofibrous scaffold will ensure that the therapeutic benefit provided by stem cells will be localized directly to the damaged area of the heart,” said NuVascular Technologies founder and Chief Technical Officer Matthew Phaneuf. “This scaffold will also prevent the cells from leaving the target area while permitting easy removal of the device, if required. We are confident that our devices can provide a minimally invasive, highly effective treatment for heart disease that can actually reverse the damage rather than providing a temporary solution that often comes with complications.”
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