长期睡眠不足易导致血压增高 甚至心脏病发作

  近日，在圣地亚哥召开的第64届美国心脏病年会上，来自梅奥诊所的研究人员表示，长期睡眠时间短的个体或许在夜间机体血压会明显升高。

  文章中，研究者对8名年龄为19至36岁的健康正常体重的个体进行研究，让其加入16天的入院研究计划中，其中包括4天的适应期，随后9天里研究者对参与者进行睡眠限制（每晚睡眠4个小时）或者正常睡眠（每晚睡眠9个小时），随后再进行3天的恢复，在每个研究阶段研究人员都对个体每天进行24小时有规律的血压监测。

  在夜间相比正常睡眠阶段，处于睡眠限制阶段的个体收缩血压和舒张血压平均为115/64 mm Hg，而正常阶段则为105/57 mm Hg；此外夜间当参与者没有经过足够睡眠的情况下，其预期的血压下降或许会被抑制，同时研究者还发现，相比正常睡眠个体而言，睡眠限制的个体在夜间往往心率会明显升高。

  研究者Naima Covassin说道，我们都知道高血压，尤其是夜间处于高血压的情况下是个体心脏病发作的主要风险因素，而我们的研究首次阐明了睡眠不充足会引发个体夜间血压的升高，进行对照研究我们发现很多经历睡眠缺失的个体都会出现机体夜间血压下降被抑制的现象，后期我们还将进行更为深入的研究来研究者睡眠时间同个体血压之间的关系，这或为开发新型疗法来缓解个体血压升高的情况提供一定的线索。（转化医学网360zhyx.com）

  以上为转化医学网原创翻译整理，如需转载，请联系 info@360zhyx.com
转化医学网推荐的新闻阅读：

Results of the study will be presented March 15 at the American College of Cardiology's 64th Annual Scientific Session in San Diego.

In this study, eight healthy, normal weight participants, ages 19 to 36, participated in a 16-day inpatient protocol, consisting of a four-day acclimation period followed by nine days of either sleep restriction (four hours of sleep per night) or normal sleep (nine hours of sleep per night), and three days of recovery. Twenty-four blood pressure monitoring at regular intervals was measured at each study phase.

During the nighttime, in the sleep restriction phase compared to the normal sleep phase, systolic (top number) and diastolic (bottom number) blood pressure averaged 115/64 millimeters of mercury (mm Hg) versus 105/57 mm Hg, respectively, researchers found. Furthermore, the expected fall in blood pressure during the night was suppressed when subjects had inadequate sleep. They also found that nighttime heart rate was higher with sleep restriction than in normal sleep.

"We know high blood pressure, particularly during the night, is one of the major risk factors for heart disease, and Americans typically do not get enough sleep," says lead author Naima Covassin, Ph.D., Mayo Clinic cardiovascular diseases research fellow. "For the first time, we demonstrated that insufficient sleep causes increases in nighttime blood pressure and dampens nocturnal blood pressure dipping by using a controlled study that mimics the sleep loss experienced by many people."