科学家发起研究来为患者匹配最佳的药物疗法

  伊丽莎白-考夫曼研究所于今日发起了一项非营利转化医学的研究，即为患危及生命的疾病的患者寻找最合适的疗法进行治疗。
  这项研究由系统生物学院的主任Lee Hood及其同事发起，以剑桥大学和麻省理工学院为基础的研究团队目前计划开发一种新型的知识库来评估患者的疾病信息，包括遗传和分子数据等，目的在于为每位患者确定最好的疗法。
  这项研究中，研究人员开发了一种独特的算法，其可以为一些难治性的疾病来帮助预测最有效的疗法，包括胰腺癌、脑癌及镰状细胞性贫血症等。
  其它研究所的发起人包括GNS医疗CEO Colin Hill；医疗中心的副主任Robert Goldberg；患者Kathleen O'Connell以及佛蒙特大学系统生物学专家Stuart Kauffman教授。该研究所是以Kauffman的妻子伊丽莎白命名的，他的妻子2013年因胰腺癌去世。
  最后研究者Hood表示，我们成立这个研究所是因为当今使用的超过一半的药物都没有在至少一半的患者机体中发挥最佳疗效，尤其是对于患严重复杂致死性疾病的患者而言，因此我们的目的就是改变当前药物的使用，为患者匹配选择出最佳的疗法，这对于减缓患者的疾病以及改善患者的生活质量将带来巨大帮助。（转化医学网360zhyx.com）
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Institute Launches to Match Patients With Most Appropriate Drugs
NEW YORK (GenomeWeb) – The non-profit Transforming Medicine: The Elizabeth Kauffman Institute (TMed), which seeks to match patients with life-threatening diseases with the most appropriate treatments, officially launched today. 

Founded by Institute for Systems Biology President Lee Hood and others, Cambridge, Massachusetts-based TMed plans to develop a knowledgebase for evaluating patient information, including genetic and molecular data, to determine the best marketed and research-stage treatment for each individual. 

Researchers at the institute will develop unique algorithms that can predict the most effective therapies for difficult-to-treat ailments including pancreatic cancer, brain cancer, and sickle cell anemia, TMed said. 

The other founders of the institute include Colin Hill, CEO of GNS Healthcare; Robert Goldberg, vice president and co-founder of the Center for Medicine in the Public Interest; Kathleen O'Connell, a patient advocate; and Stuart Kauffman, a systems biology expert at the University of Vermont. 

The institute is named for Kauffman's wife Elizabeth who died in 2013 from pancreatic cancer. 

"We formed this institute because over half the medicines used today do not work for half the patients," Hood said in a statement. "This is particularly true for people fighting the most complex and fatal diseases. Our aim is to change the practice of medicine in a fundamental way."