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腾讯登录纽约基因组中心获得NHLBI精准医疗项目资助1350万美元
| 导读 | 纽约基因组中心近日宣布，其获得了国家心脏，肺和血液研究所的Trans-Omics精准医疗（TOPMed）项目资助1350万美元进行相关研究。 |
TOPMed项目计划整合基因组测序和其他组学数据，比如代谢组学，蛋白质表达组学和RNA表达组学，与从临床中获得的分子，行为，成像，环境数据一起，研究心脏，肺，血液和睡眠障碍的疾病。其目标是发现疾病的风险因素，并确定相关亚型，然后开发具有针对性的疗法。
该项目是从一个全基因组测序项目，涉及到具有良好的临床表型和结果的个体，发展而来的，之前的项目获得了NHLBI的资助，现在起计划将这个计划发展成一个更大规模的项目。NYGC为了TOPMed项目已经对1500名志愿者进行了测序和相关分析，其计划使用新获得的资助进一步扩大相关项目的规模。
为了支持这个和其他项目，该中心最近从Illumina公司额外购买了4台HiSeq X10仪器，该型号仪器总数达到了14台。到今年年底，其预计将有超过10000个志愿者完成相关的基因组测序。
Broad研究所也参与了TOPMed项目，该研究所这个月早些时候曾经从NHLBI获得了4000万美元的资助，已完成该项目20000个志愿者的全基因组测序。
原文：
The New York Genome Center has won $13.5 million under the National Heart, Lung and Blood Institute's Trans-Omics for Precision Medicine (TOPMed) program, the center said today.The TOPMed program plans to combine whole-genome sequencing and other omics data, such as metabolic, protein expression, and RNA expression data, with molecular, behavioral, imaging, environmental, and clinical data from studies focused on heart, lung, blood, and sleep disorders. The goal is to discover risk factors for the diseases, identify subtypes, and develop targeted treatments.
The program is starting with a whole-genome sequencing project involving individuals with well-defined clinical phenotypes and outcomes from earlier NHLBI-funded studies, which is expected to develop into a larger initiative.
The NYGC has already sequenced and analyzed 1,500 human genomes for the TOPMed program and will expand this effort with the new funding.
To support this and other projects, the center recently purchased four additional Illumina HiSeq X Ten instruments, bringing its total to 14. By the end of this year, it expects to have sequenced more than 10,000 human genomes.
The Broad Institute is also participating in the TOPMed project— the institute said earlier this month that it won $40 million from NHLBI to sequence 20,000 individuals under the program.（转化医学网360zhyx.com）
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