【重磅研究】时空分子医学:临床转化医学的新时代
导读 | 【编者按】近日复旦大学附属中山医院樊嘉院士和王向东教授在国际临床转化医学杂志(Clin Transl Med,https://onlinelibrary.wiley.com/doi/full/10.1002/ctm2.294; 影响因子7.9)上率先提出来“时空分子医学”这个新概念,把临床医学和分子医学上升到了一个新高度,将成为临床转化医学的新世纪。时空分子医学以贯穿传统临医学、现代医学、未来医学为主题,使临床医学多维化:把临床医学的时间概念、空间概念、分子概念和整个医学概念融为一体。时空分子医学将为未来临床医学在疾病的预防、诊断、治疗、预后方面起到重要的指导作用。 |
本文作者为复旦大学附属中山医院樊嘉、王向东,题目:Spatiotemporal molecular medicine: A new era of clinical and translational medicine。2021年1月17日正式在 Clin Transl Med 杂志发表(2021 Jan;11(1):e294. doi: 10.1002/ctm2.294)。
总之,我们提出了时空分子医学作为一门新兴的医学学科的概念,并相信随着时空转录组学、蛋白质组学和代谢组学的发展,时空分子医学将变得更加重要和适用。时空化的临床表型和组学信息相结合,形成了对患者的四维理解、诊断和治疗。时空测量和分析是限制时空分子医学临床应用的关键因素。尽管面临诸多挑战,时空分子医学将提高我们对疾病的认识,为精准早期诊断和治疗提供多维和靶向依据,并将成为临床转化医学的主题之一。
( 感谢复旦大学中山医院刘小霞医生原文翻译,武多娇主任校对。)
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